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William Higgins was driving south on Route 5 in Enfield when he left the road, went through a wooded grassy area onto I-91, and crashed into the truck around 2:30 p.m., Connecticut State Police said.
Paramedics rushed the Enfield man to Hartford Hospital, where he died of his wounds.
Responders also took the Lot and More work truck driver to the hospital for minor injuries.
Police are investigating the crash.
Authorities ask anyone who saw the crash or has any information about it to contact Trooper Michael Dean at 860-534-1098 or Michael.Dean@ct.gov.
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